USA coach Jurgen Klinsmann says they will banish their curse in matches against Ghana at 2014 World Cup when the two sides meet in the opening match of their group.
The two countries were drawn on Friday to face each other in the opening match of the group which includes Germany and Portugal.
The game will be the third successive time the two sides would meet at the World Cup with the Black Stars winning in the two previous occasions.
The USA will also play Ghana in Natal on 16 June having twice lost to the Black Stars.
Ghana eliminated America in the tournaments of 2006 and 2010 which has sparked fresh fears among the Americans that the dose could be repeated.
But Klinsmann says they must now defeat the Black Stars to prove that they have improved over the past two and half years.
“Now is the time to beat them,” said Klinsmann.
Black Stars will play Germany in Fortaleza on 21 June in Group G, having also drawn Portugal and USA.