Giants Asante Kotoko will host second tier club Istanbul FC while New Edubiase are on the road to Fetteh Feyenoord.
The Round of 16 stage is however bedevilled by outstanding fixtures due to prolonged disciplinary issues.
Two fixtures in the Round of 16 stage remain uncertain due to this setback.
The Round of 16 fixtures will be cleared on 20-23 February.
Below is the full Round of 16 Fixtures:
Asante Kotoko vrs Istanbul FC
Berekum Chelsea vrs Inter Allies
Hasaacas vrs Gold Stars
Fetteh Feyenoord vrs New Edubiase
AshantiGold vrs Mighty Jets
Rospack/Right to Dream/Ho Dynamos/ King Faisal vrs Metro Stars
Okwawu United vrs Medeama
Aduana Stars/Asokwa Deportivo/Dunkwa United/Dawenya United/Royal Faith FC/ Bazooka vrs Bechem United