Sulley Muntari and Michael are likely to play in the heart of defense for AC Milan in their Seria A clash against Roma on Saturday.
The Ghanaians were second hald substitute in their 2-0 win over Napoli last weekend.
Muntari returned from a two-week injury lay off to help the side to victory while Essien has enjoying some regular playing time lately.
With doubts surrounding De Jong, the two Ghanaian stars could be called into duty at the Stadio Olimpico.
Milan have won just twice in their last eight games in what is turning out to be an indifferent season.