Medeama will open their defence of the MTN FA Cup title away to Score FC as revealed by the draw held on Wednesday.
The Yellow and Mauves, just like all other Premier League clubs drew byes in the preliminary rounds of the competition.
The 16 top flight clubs will now be joining the competition at the Round of 64 stage.
Last year’s finalists Asante Kotoko will also be away to either Tamale Liberty or or Waiga United while Hearts of Oak are in the road to Gold Stars.
2011 winners Nania FC are at home to DC United while their successors New Edubiase also host BolgaMan City.
The games at this stage will be played between December 18-23.
Round of 64 fixtures:
Inter Allies vs Berlin FC
Mighty Jets vs Mepe United
Tarkwa United vs Hearts of Lions
Rospac FC vs Right to Dream FC
Bubiashie Charity Stars vs Liberty Professionals
Dawhyenya FC / Royal Faith vs Bazooka FC
Metro FC vs Esperance
New Edubiase vs Bolga Man City
Ebusua Dwarfs vs First Klass FC
Tamale Liberty/Waiga Utd vs Asante Kotoko
Future Stars vs Bofoakwa
Okwahu United vs Real Athletico
Bolga All stars/Crystal Palace vs Believers FC
Nania FC vs DC United
Aduana Stars vs Asokwa Deportivo / Dunkwa United
King Faisal vs Tuobodom Santos
Real Tamale United vs UCC Youngsters
Feyenoord Academy vs Wa All Stars
Red Lions FC vs Binduri United
Berekum Chelsea vs Wenchi United
Gold Stars vs Accra Hearts of Oak
Starke FC vs Hasaacas
Kessewa International vs Kotoku Royals
Prestige FC vs Istanbul FC
Ash Gold vs BA United
Amidaus Professionals vs Danbort FC
Score FC vs Medeama
Sampa United vs Bagotek
Tumu Happy Stars vs Tema United
Dolphins FC vs Guan United
Pure Joy vs Ajax Fc
Bechem United vs Cape Coast Strikers