Midfielder Daniel Larbi Koomson is among five high-profile players put on the transfer list by Medeama.
Koomson alongside Seidu Yakubu, Sabato Mohammed, Kassim Adams and Jacob Kwaw have been told look elsewhere.
Experienced midfielder Eric Nyarko, who joined from Israeli outfit Hapoel Kfar Saba, has left after he was refused a new deal.
The Mauves and Yellows have embarked on a massive clear-out ahead of the start of the new season and their involvement in the CAF Confederation Cup next year.
Officials have also revealed new players will be bought to augment the current squad.