Champions Asante Kotoko must beat Real Tamale United on Boxing Day to breathe life back into their title defence.
The Porcupine Warriors suffered their first defeat of the season after going down 2-0 at Berekum Chelsea.
Kotoko will be without defender Kwabena Adusei who was sent off in their match against Chelsea.
Head coach Mas-Ud Dramani blames his defence for their defeat and must fix it before playing RTU at the Baba Yara Stadium.
Real Tamale United are yet to record their first win of the campaign and do not look like a side capable of causing havoc.
The Pride of the North have managed just four points from the available 24 and have emerged as of the candidates for relegation.