Juventus manager Antonio Conte is considering the use of Kwadwo Asamoah in central midfield against Sassuolo.
The Ghana international has been mainly used as a left-wing back since his arrival from Udinese two years ago.
However, with Andrea Pirlo injured and Claudio Marchisio suspended, Contecould bring the 25-year-old into the middle.
If Asamoah is kept on the flank, then Simone Padoin will be fielded instead.
According to reports Fabio Quagliarella may start in attack alongside either Carlos Tevez or Fernando Llorente.