Hearts of Oak are without influential duo Emmanuel Hayford and Robin Gnagne for their trip to Bechem United.
The Phobians have lost defender Gnagne through a shoulder injury sustained in last weekend’s 3-2 win over Inter Allies.
The Ivorian import has failed to make a recovery in time to join the Hearts team for Saturday’s game at Bechem.
Coach David Duncan has also lost midfielder Emmanuel Hayford who has been battling an ankle injury since the start of the season.
Both players were left behind in Accra on Friday morning as the team departed for Bechem for Saturday’s Premier League match.
Hearts could topple rivals Asante Kotoko at the summit of the Ghanaian top flight if they beat Bechem United ahead of remaining Premier League fixtures on Sunday.