Appiah left out the three experienced players for varied reasons following his side’s disappointing performance at the 2013 Nations Cup.
Right-back Pantsil is yet to recover from an injury he sustained during the semi-final defeat to Burkina Faso in South Africa.
Midfielder Annan has also been overlooked after returning to the pitch only last week since recovering from a knee setback that plagued his involvement in the continental showpiece in South Africa.
Boateng has paid the a heavy price for his unconvincing display at the tournament.
In their absence coach Appiah has called-up four debutants – Baba Abdul Rahman, David Accam, Mahatma Otoo and Yaw Frimpong.