Ghana will begin their 2013 Africa Cup campaign against DR Congo in Port Elizabeth on 20 January.
The Black Stars will be facing the Leopards coached by former Ghana coach Claude Le Roy who is well travelled on the continent.
The Frenchman was on the Ghana bench at the 2008 Africa Cup of Nations where he won bronze with the hosts.
At the 1996 tournament also hosted by South Africa, Ghana beat then Zaire 1-0 in the quarter-final match.
The two sides last met in 2005 in a qualifier to the 2006 FIFA World Cup which ended in a 1-1 draw played in Kinshasa.
Ghana’s second Group B match will be against old foes Mali, Group opponents at the last edition of the Cup of Nations in Gabon and Equatorial Guinea.
Kwesi Appiah side’s will play their final match against West African neighbours Niger on 28 January.
Ghana finished fourth at the last edition.