Medeama lost 2-1 to second-tier side Eleven Wise in their latest pre-season friendly on Sunday.
The giants of the West scored through Daniel Berko and Osmane Mohammed before Francis Addo pulled a goal back for the Medeama at the Tarkwa and Aboso Park.
The two sides are using the friendly to prepare for the start of their respective league games which has been delayed by a court action.
The two sides will clash again at the Essipong stadium on November 30.